TRANSESTERIFICATION REACTIONS CATALYZED BY CHYMOTRYPSIN
نویسندگان
چکیده
منابع مشابه
Transesterification reactions catalyzed by chymotrypsin.
As recently reported, the behavior of acetyl chymotrypsin with ethanol consists in a rapid transfer of the single acetyl group to that alcohol with the formation of ethyl acetate (1). Thus, the splitting of nitrophenyl acetates by chymotrypsin, faster in ethanolic than in aqueous solutions, may be explained by the formation of acetyl chymotrypsin as an intermediate and its subsequent preferenti...
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The hydrolysis of a series of esters of benzoyl-L-arginine and glycylglycine by papain has been examined in mixtures of water with various alcohols in the pH range of 5 to 6. The presence of straight chain alcohols resulted in an apparent inhibition of acid release. It was shown that this inhibition could, in part, be accounted for by papain-catalyzed transesterification reactions between the v...
متن کاملThe Mechanism of Chymotrypsin-catalyzed Reactions.
In two recent papers" 2 it has been suggested that the reaction of chymotrypsin with its substrates proceeds by way of three kinetically distinct steps. First there occurs a rapid initial "adsorption" of the substrate on the specificity site of the enzyme. The second step involves the acylation of a group on the enzyme by the acidic part of the substrate, with concomitant liberation of the nona...
متن کاملTransesterification of trimethylphosphate catalyzed by sodium aloxides
The transesterification process of trimethylphosphate with ethanol and isopropanol is examined. It is found that the reaction does not proceed in the absence of base even at temperature up to 100°C, whereas in the presence of sodium alkoxide as a catalyst it takes place at room temperature leading to a mixture of mono-,bi-, tri-substitute esters as well as the minor by-products resulting from t...
متن کاملtransesterification of trimethylphosphate catalyzed by sodium aloxides
the transesterification process of trimethylphosphate with ethanol and isopropanol is examined. it is found that the reaction does not proceed in the absence of base even at temperature up to 100°c, whereas in the presence of sodium alkoxide as a catalyst it takes place at room temperature leading to a mixture of mono-,bi-, tri-substitute esters as well as the minor by-products resulting from t...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1956
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)65212-3